Fidelity's Joel Tillinghast, one of the mutual fund industry's best stock pickers over the past 20 years, said financial markets are "colossally artificial" and cited ride-sharing upstart Uber and negative yielding government bonds as examples.

"I think it's colossally artificial, but I don't see it ending," said Tillinghast, who runs the $46 billion Low-Priced Stock Fund for Fidelity Investments in Boston. He made his remarks on Friday in a rare interview.

Tillinghast pointed to unprecedented central bank intervention around the globe over the past 10 years in the form of quantitative easing, which has resulted in government bonds with negative yields in countries such as Germany, Switzerland and Denmark.

He said he was also incredulous that privately held Uber Technologies is valued at more than $40 billion by venture capitalists and mutual fund investors that include Fidelity.

"So this high-tech taxi service is selling for three times the price of all the medallions in New York City," Tillinghast said. "Subjectively, I think that's a bubble, even if it is a fantastic service."

Over the past 20 years, Tillinghast's fund has generated an annualized total return of 13.29 percent. That far exceeds the 9.35 percent total return of the Russell 2000 Index during that period and the Standard & Poor's 500 Index's total return of 9.28 percent, according to data from Lipper Inc, a Thomson Reuters unit.

When compared to nearly 3,500 actively managed stock mutual funds, Fidelity Low-Priced Stock Fund ranked 17th for the 20-year period that ended April 30, according to Lipper. Tillinghast's stewardship of the fund spans more than 25 years. The fund's 1-year return of 13.03 percent is beating 70 percent of peers, according to Morningstar Inc.

He said he has stayed put with Fidelity, instead of running a hedge fund, for example, because he likes working with and being challenged by colleagues such as Contrafund's Will Danoff and Bill Bower of the Diversified International Fund.

"Fidelity is somewhat bureaucratic, but compared with what is out there, they mostly let me do my job, and not do all the stuff I'm not good at, that I don't want to do," such as calming nervous clients, Tillinghast said.

"And the people I know who have gone to hedge funds hate sucking up to clients."

Tillinghast focuses on mid-cap stocks that typically cost less than $35 a share. At the end of the first quarter, his three largest picks were UnitedHealth Group Inc, Next Plc and Seagate Technology Plc, respectively. His fund's annual turnover rate is about 11 percent, an indication that he is patient with his selections.