Donald Trump has vowed to scrap Biden's digital-asset clampdown and appoint friendly regulators.
The crypto rally is driving peak trading volumes and inflows at U.S. bitcoin exchange-traded funds.
The largest token has jumped about 32% since the US election on Nov. 5.
The token is continuing to price in a Donald Trump election victory, analysts say.
Bitcoin climbed nearly 10% in the seven days through Sunday.
Bitcoin's tumble comes despite a streak of inflows into ETFs for the original cryptocurrency.
Some see the cryptocurrency's slide as a sign that investors are growing averse to risk.
The cryptocurrency suffered another bout of its notorious volatility.
Smaller tokens such as Ether and meme-crowd favorite Dogecoin also pushed higher.
Optimists argue spot bitcoin funds will help spur wider crypto adoption.