After a strong 2020, so-called stay-at-home stocks clearly struggled through 2021's gradual reopening of the world's economies.

Though new Covid variants may cause yet another reversal of the trend, many of the Nasdaq-100's worst-performing stocks are major names from the stay-at-home technology universe, a group meant to sustain a workforce reluctant or unable to return to the office or that entertained locked-down families via video games, movies and other activities.

Chinese technology stocks also clearly suffered--many were delisted from U.S. exchanges and faced regulatory uncertainty at home.

Here, in descending order, are the 10 worst performing Nasdaq stocks as of December 21.

10. JD.com -16.4%

A Chinese e-commerce provider (also known as Jingdong) JD stock fell from $87.90 at the beginning of the year to $73.52 on December 21.

9. PayPal -19.8%

Online payments stalwart PYPL dropped from $234.20 to $187.74.

8. MercadoLibre -27.0%

Argentinian e-commerce megacap MELI saw its price fall from $1675.22 to $1223.00.

7. DocuSign -30.5%

While DOCU became ubiquitous in many financial advisors' workflows, its stock dropped from $222.30 to $154.46.

6. Activision Blizzard -31.7%

ATVI, whose video game franchises include Warcraft, Diablo and Starcraft, fell from $92.85 to $63.44.

5. Baidu -33.2%

BIDU, a Chinese artificial intelligence giant, saw its stock price fall from $216.24 to $144.40.

4. Splunk -33.4%

SPLK, which offers automated data analytics, dropped from $169.89 to $113.10.

3. Zoom Video -41.1%

Investors also suffered from Zoom fatigue in 2021, sending ZM plummeting from $337.32 to $198.70.

2. PinDuoDuo -66.5%

PDD, a Chinese agriculture-focused e-commerce platform, fell from $177.68 to $59.46.

1. Peloton -74.2%

PTON, offering connected home workout equipment, saw its stock open 2021 at $151.72 and then decline to $39.13 over the course of the year.