The results shine a new light on how much Platform Solutions has been dragging down the firm's bottom line.
Pruzan departs after a 28-year run that included a six-year stint as chief financial officer.
More than a third of those will likely be from within its core trading and banking units.
The proposed cuts would mark a sharper pullback than plans disclosed by any of Goldman's rivals.
Top managers have been asked to identify potential cost-reduction targets.
CEO David Solomon has recently also signaled he's reviewing other business lines to manage headcount and limit costs.
Solomon said the US could see a recession in 2023, even though the firm's economists say it could still avoid one.
Goldman Sachs and Bank of America executives have also warned of hiring slowdowns.
Some wealth advisers have been growing cautious about client exposure to illiquid assets in recent months.
The partner worked in posts around the C-suite, met with top executives and held senior positions in one of the firm's divisions.
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