Initial small-scale Fresno trials in 2016, run by an upstart called MosquitoMate, were the first time male Aedes aegypti mosquitoes infected with the bacteria were ever released in the U.S. The following year, Verily stepped in, bringing more advanced technology to the breeding and release process that could make it possible to expand such efforts to entire cities or regions.

The new paper details many of those technologies, such as an automated process for separating male and female mosquitoes in the lab, and software that helps to determine exactly where to release altered male mosquitoes for maximum effectiveness.

“Once you try to start rearing hundreds of thousands of mosquitoes a week, you run into all sorts of problems,” said White. “Mosquitoes may be everywhere, but they are really finicky and difficult to grow.”

Verily has expanded its partnerships to include Singapore’s National Environment Agency. Trials there have entered a fourth phase to cover 121 urban residential blocks and about 45,000 residents. Verily is eyeing partnerships in South America and is in talks to launch in the Caribbean.

Within a few years, said Crawford, Verily hopes the program will cover entire regions. Without intervention, he said, the public health toll of mosquito-born illness will only grow.

“This is something that’s not going away on its own,” he said.

This article was provided by Bloomberg News.

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