BlackRock Inc. is launching its largest sweeping organizational overhaul in years, according to an internal memo.

The world’s largest asset manager is installing new leaders at its alternatives investment division, reorganizing staff and shifting more responsibility for clients to regional leaders, according to the memo to staff Tuesday.

“Today we are making a number of changes designed to ensure we stay ahead of our clients’ and society’s needs,” BlackRock Chief Executive Larry Fink and President Rob Kapito wrote in the memo.

The changes come amid speculation about who will succeed Fink, 66, as the firm’s CEO. A handful of executives are considered to be in the running, including two whose roles are shifting, according to the memo. In recent years these proteges have been shuffled in a variety of senior positions and Fink has said he prefers not to let one clear successor emerge.

Two men thought to be contenders received new responsibilities. Mark McCombe will take on the newly created role of chief client officer. Mark Wiedman -- who earlier this year also got a new job as head of international and corporate strategy -- will take on Latin America.

The firm said it is establishing Latin America as a region organizationally in parallel with Asia-Pacific and Europe, the Middle East and Africa, or EMEA.

Asset managers are under pressure as volatility roils markets and investors pile into low-fee funds. The industry is deploying technology across its businesses to reduce costs and expanding its offerings in alternatives such as private equity and real estate, which usually charge higher fees.

Edwin Conway, who previously led BlackRock’s interactions with institutional clients, will become global head of the alternatives business, according to the memo. Jim Barry, the firm’s head of real assets within the unit, will become investment chief for the group.

BlackRock has sought to expand beyond indexed products, which account for about two-thirds of assets under management, and bolster its alternatives business. On Monday the New York-based company, with about $6 trillion in assets, said it had completed its first fundraising round for a private equity vehicle. The Long Term Private Capital fund secured $2.75 billion from investors, Bloomberg reported yesterday.

Other moves outlined in the memo include:

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