Among the leading candidates to replace Lew as Obama’s chief of staff are Denis McDonough, currently a deputy national security adviser, and Ron Klain, who had served as Vice President Joe Biden’s chief of staff.

McDonough, who worked as an aide to former Senator Tom Daschle as well as in Obama’s Senate office, joined the National Security Council as deputy director of strategic communications at the start of Obama’s term. When Tom Donilon became the NSC director after General Jim Jones departed, McDonough became an assistant to the president and the deputy national security adviser.

Klain served as chief of staff to both Biden and former Vice President Al Gore. In January of 2011, he left the White House and returned to Case Holdings, the holding company of AOL co-founder Steve Case and served as an outside adviser to Obama.

Neither McDonough nor Klain responded to e-mails seeking comment.

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