Altria, which makes the Marlboro brand cigarettes, was the biggest drag on the S&P 500 and weighed heavily on the consumer staples sector, which was the worst-performing group.
U.S.-traded shares of British American Tobacco dropped 7.3 percent.
Exxon shares fell 1.9 percent after a rare earnings miss, while shares of rival oil major Chevron climbed 1.7 after its results.
Starbucks plunged 10.0 percent and Mattel dropped 8.4 after their respective reports.
Following the failure of Senate Republicans to dismantle the Affordable Care Act, investors were also weighing the impact on the rest of President Donald Trump's agenda, including tax cuts, that has supported the stock market.
Declining issues outnumbered advancing ones on the NYSE by a 1.03-to-1 ratio; on Nasdaq, a 1.36-to-1 ratio favored decliners.
This article was provided by Reuters.