Sarah Bloom Raskin withdrew as President Joe Biden’s nominee to be the Federal Reserve’s vice chair of supervision, people familiar with the matter said, after it became clear she didn’t have the votes to be confirmed.

Raskin’s chances for the post evaporated after Senator Joe Manchin of West Virginia, a pivotal Democratic vote in the 50-50 Senate announced he wouldn’t support her. Senator Susan Collins of Maine, a Republican moderate who is often a target for Democrats seeking a GOP vote, also announced her opposition.

Raskin blamed “relentless attacks by special interests” on her views on climate change and “diversionary attacks on my ethics and character,” in a letter to Biden cited by the New Yorker, which first reported her withdrawal.

Raskin, 60, who also faced a Republican blockade in the Senate Banking Committee, had been strongly supported by progressive groups and Senate Democrats like Elizabeth Warren of Massachusetts, who praised her advocacy for regulators to take on financial risks from climate change. Supporters also cited her long experience as a bank regulator and former Fed governor and deputy Treasury secretary.

But that climate advocacy also helped sink her nomination with Manchin -- a supporter of expanding fossil fuel production who represents a coal-rich state -- and many Republicans.

“Her previous public statements have failed to satisfactorily address my concerns about the critical importance of financing an all-of-the-above energy policy to meet our nation’s critical energy needs,” Manchin said Monday in a statement.

Raskin’s withdrawal could clear a path for quick confirmations of Biden’s other Fed nominees, including the renomination of Jerome Powell for a second term as Fed chair, the elevation of Fed Governor Lael Brainard to vice chair, and the nominations of Lisa Cook and Philip Jefferson. Powell, Brainard and Jefferson have at least some public bipartisan backing. All of them had been caught up in the Republican opposition to Raskin.

In the 50-50 Senate, opposition from Manchin has doomed much of Biden’s sweeping domestic agenda and multiple nominations, including the president’s first choice for budget director, Neera Tanden.

While the White House and Banking Committee Chairman Sherrod Brown of Ohio had vowed to press forward anyway with her nomination, there was no clear path to getting additional Republican votes or clearing the committee boycott led by Pat Toomey of Pennsylvania, the top Republican on the panel. Toomey and other Republicans on the committee refused to show up for votes, saying they were unsatisfied by Raskin’s answers regarding her role in Colorado fintech firm Reserve Trust getting a valuable Fed master account while she served as a company director.

Under Senate rules, a committee must have a quorum to move a nominee to the floor, or there must be 60 votes on the floor to discharge the nominee from the committee. Democrats theoretically could have changed the Senate votes to advance her, but that would have, again, likely required getting Manchin’s support to change rules to confirm a climate advocate, when he has opposed changing the rules to enact any other piece of Biden’s agenda.

Another top regulator pick made by Biden, Comptroller of the Currency nominee Saule Omarova, withdrew from consideration last year amid Democratic resistance and concerns regarding her views about fossil fuel companies. Omarova faced bipartisan criticism after a tape emerged of her saying she wanted smaller companies in the fossil fuel industry to go “bankrupt,” a remark she tried to walk back under questioning from senators.

Because the Fed is charged with monitoring Goldman Sachs Group Inc., JPMorgan Chase & Co. and other massive financial firms, the post of vice chair for supervision is seen as the most powerful bank regulator in Washington. In addition to setting rules in arcane areas that go right to lenders’ bottom lines like balance-sheet liquidity and capital levels, the person in that position would oversee closely-watched annual stress tests that review bank safety.

--With assistance from Laura Litvan and Max Reyes.

This article was provided by Bloomberg News.