One of every four deaths in the U.S. is due to cancer, making it the second leading killer in the nation behind heart disease, according to a new report by the U.S. Centers for Disease Control and Prevention.

The scourge of cancer, however, is greater in some states than others. Reader's Digest analyzed newly released CDC data and identified which states had the highest rate of new cancer cases between 2010 and 2014.

The publication noted that the overall U.S. rate of new cancer cases during that time was 452 per 100,000 people, but cautioned that people shouldn't panic if their state is above that average.

"An important thing to know about cancer rates: The better a state is at screening for cancer, the more disease it will find; in other words, don't despair if your state happens to be in the top 20 list," the Reader's Digest report said. 

The report also noted that state's with a high rate of cancer cases may not necessarily rank high in the rate of cancer deaths. "Your state could have a great track record of treating cancer and helping people survive," the magazine reported.

These, in ascending order, are the states with the highest rate of new cancer cases, according to Reader's Digest:

10. Rhode Island

480 cases per 100,000

The state has a high rate of lung cancer deaths, and its cancer death rate is 170 per 100,000, which is slightly higher than the national rate of 166, according to Reader's Digest, adding that the poor survival rates for lung cancer sufferers may explain the state's higher-than-average death rate.