"You could pay off a percentage of it, depending on how aggressive you want to be," he said. "I'd rather not be all that aggressive. I'd rather not have debt, but we're stuck with it."
Trump rival Ted Cruz, a U.S. Senator from Texas, has said he would audit the Federal Reserve and move to a rules-based monetary policy.
Other U.S. presidential candidates, including Democrat Bernie Sanders, have also vowed changes to the Fed.