The probe is digging into how hedge funds tap into research and set up their bets.
Libor rigging was one of the most sweeping abuses involving Wall Street to emerge in the wake of the 2008 financial crisis.
The biggest award given to a whistle-blower was $114 million in October 2020.
The San Francisco robo-advisor transferred clients' assets without informing them, the SEC says.
The regulator is applying its enforcement powers in the booming decentralized finance market.
Some want tougher rules governing how U.S. corporate executives buy and sell their own companies' stock.
Neither the whistle-blowers nor the firm accused of misconduct were named by the SEC.
Alex Oh cited a complication in a case from her prior legal career as her reason for stepping down.
She previously served as an Assistant U.S. Attorney for the Southern District of New York.
The examination is in its early stages and is being led by the agency's asset-management group.
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