After a strong 2020, so-called stay-at-home stocks clearly struggled through 2021's gradual reopening of the world's economies.

Though new Covid variants may cause yet another reversal of the trend, many of the Nasdaq-100's worst-performing stocks are major names from the stay-at-home technology universe, a group meant to sustain a workforce reluctant or unable to return to the office or that entertained locked-down families via video games, movies and other activities.

Chinese technology stocks also clearly suffered--many were delisted from U.S. exchanges and faced regulatory uncertainty at home.

Here, in descending order, are the 10 worst performing Nasdaq stocks as of December 21.

10. JD.com -16.4%

A Chinese e-commerce provider (also known as Jingdong) JD stock fell from $87.90 at the beginning of the year to $73.52 on December 21.